Prophylaxis of Candida albicans infection in neutropenic mice with liposome-encapsulated amphotericin B.
نویسندگان
چکیده
The efficacy of liposome-encapsulated amphotericin B in the prophylaxis of disseminated Candida albicans infections in neutropenic mice was studied. The administration of liposome-encapsulated amphotericin B was associated with protection against infection with C. albicans when used at doses of greater than or equal to 2 mg of amphotericin B per kg of body weight. Neither empty liposomes nor free amphotericin B showed prophylactic efficacy.
منابع مشابه
In vitro antifungal activities of amphotericin B and liposome-encapsulated amphotericin B.
The in vitro activities of liposome-encapsulated amphotericin B and free amphotericin B against Candida albicans 336 were comparable. Amphotericin B concentrations 12-fold and greater than 50-fold higher were required to kill the same organism when cholesterol and ergosterol were incorporated into the liposomes. The addition of cholesterol to liposomes caused a significant increase in the minim...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 25 3 شماره
صفحات -
تاریخ انتشار 1984